Participants Needed for a Paid Research Study on Hyperemesis Gravidarum
Research on HG's short- and long-term effects is desperately needed and needed now. We need to do more to find a cure for this disease that has such devastating effects on a growing number of soon-to-be mothers.
- Xavier Becerra
Current Research
Currently, the HER Foundation is researching many aspects of HG but focused on:
- genes involved in nausea/vomiting of pregnancy
- impact of nutritional supplementation
- accuracy and application of the HELP Score
- treatment of HG
- provider, ER, and hospital care.
Please join our studies, support our work, and help tomorrow’s mothers and babies.
Latest Publications
Recent Publications
- Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting(opens in new tab) -- Nature Genetics, 2026
- Glucocorticoid treatment, lower growth and differentiation factor 15 concentrations, and improved hyperemesis gravidarum symptoms(opens in new tab) -- Am J of Ob Gyn, Research Letter, 2026
- Prepregnancy metformin use associated with lower risk of severe nausea and vomiting of pregnancy and hyperemesis gravidarum (opens in new tab)-- Am J of Ob Gyn, Original Research, 2026
- Prepregnancy metformin use associated with lower risk of severe nausea and vomiting of pregnancy and hyperemesis gravidarum(opens in new tab) -- Am J of Ob Gyn, 2025
- Risk Factors for Infusions, Emergency Room Visits and Hospitalizations for Hyperemesis Gravidarum: New Data and Literature Review(opens in new tab) -- International J of Women's Health, 2024
- Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes(opens in new tab) -- Trends in Molecular Medicine, 2024
- GDF15 linked to maternal risk of nausea and vomiting during pregnancy(opens in new tab) -- Nature Journal, 2023
- Pregnant, Miserable, and Starving in 21st Century America
(opens in new tab)-- Am J of Ob Gyn, Clinical Opinion, 2022
Why More Research Is Needed
First we found the gene(opens in new tab),
Then we found the mutation(opens in new tab),
Now we found the mechanism(opens in new tab),
Help us find the cure!
Donate to HER.
Our Research
The HER Foundation(opens in new tab) research team is one of only a few teams in the world dedicated to researching hyperemesis gravidarum (HG). Our goals are to
- ensure all mothers receive needed medical care(opens in new tab),
- prevent consequences(opens in new tab) of HG
- develop resources to effectively manage HG(opens in new tab), and
- give mothers and babies a chance at a healthy future.
Research Findings
HER Foundation research is directed by Dr. Marlena Fejzo (Board Member and Research Advisor) in conjunction with leading universities such as USC.
Grant funding is rare for HG. Please support our research.
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Popular Publications
- Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes(opens in new tab) -- ScienceDirect Opinion, 2024
- GDF15 linked to maternal risk of nausea and vomiting during pregnancy(opens in new tab) -- Nature Journal, 2023
- Pregnant, Miserable, and Starving in 21st Century America
(opens in new tab)--AJOG Clinical Opinion, 2022 - HyperEmesis Level Prediction (HELP Score)(opens in new tab) Identifies Patients
with Indicators of Severe Disease: a Validation Study
-- Geburtsh Frauenheilk, 2021 (German & English) - A patient–clinician James Lind Alliance partnership to(opens in new tab) identify research priorities for hyperemesis gravidarum(opens in new tab)
-- BMJ, 2020 - Nausea and vomiting of pregnancy and hyperemesis gravidarum
(opens in new tab)-- NATURE REVIEWS | Disease Primers, 2019 (Supplemental material(opens in new tab); poster(opens in new tab))
Research Studies by Subject
Other Resources
Other Research & Presentations
- Performance of iPhone Hyperemesis Gravidarum Care App
(opens in new tab)-- J Clinical Case Rep Case Studies, 2019 - SMFM 2019 Genetics Poster(opens in new tab)
(opens in new tab) - Research Presentation Poster:
Familial Aggregation of HG(opens in new tab)
(opens in new tab) - Research Presentation Poster:
Secular Trends in the Treatment of Hyperemesis Gravidarum(opens in new tab) - Research Presentation Poster:(opens in new tab)
Extreme Weight Loss and Extended Duration of Symptoms Common in Hyperemesis Gravidarum(opens in new tab)(opens in new tab)
HER Foundation FCOI Policy
- NIH FCOI Policy
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