Participants Needed for a Paid Research Study on Hyperemesis Gravidarum
Wondering about metformin and HG? Looking for information on metformin and HG? Learn more about the clinical trials on metformin use prior to pregnancy.
Research on HG's short- and long-term effects is desperately needed and needed now. We need to do more to find a cure for this disease that has such devastating effects on a growing number of soon-to-be mothers.
- Xavier Becerra
Current Research
Currently, the HER Foundation in collaboration with Dr. Marlena Fejzo, HER Research Advisor & USC professor, is researching many aspects of HG but focused on:
- genes involved in nausea/vomiting of pregnancy
- impact of nutritional supplementation
- accuracy and application of the HELP Score
- treatment of HG
- provider, ER, and hospital care.
Please join our studies, support our work, and help tomorrows mothers and babies.
Latest Publications
Recent Publications
- GFRAL genetic variations and circulating GFRAL in
hyperemesis gravidarum -- iScience, A Cell Press Journal, 2026 - Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting -- Nature Genetics, 2026
- Glucocorticoid treatment, lower growth and differentiation factor 15 concentrations, and improved hyperemesis gravidarum symptoms -- Am J of Ob Gyn, Research Letter, 2026
- Prepregnancy metformin use associated with lower risk of severe nausea and vomiting of pregnancy and hyperemesis gravidarum -- Am J of Ob Gyn, 2025
- Risk Factors for Infusions, Emergency Room Visits and Hospitalizations for Hyperemesis Gravidarum: New Data and Literature Review -- International J of Women's Health, 2024
- Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes -- Trends in Molecular Medicine, 2024
- GDF15 linked to maternal risk of nausea and vomiting during pregnancy -- Nature Journal, 2023
- Pregnant, Miserable, and Starving in 21st Century America
-- Am J of Ob Gyn, Clinical Opinion, 2022
Our Research
The HER Foundation research team is one of only a few teams in the world dedicated to researching hyperemesis gravidarum (HG). Our goals are to
- ensure all mothers receive needed medical care,
- prevent consequences of HG
- develop resources to effectively manage HG, and
- give mothers and babies a chance at a healthy future.
Research Findings
HER Foundation research is directed by Dr. Marlena Fejzo (Board Member and Research Advisor) in conjunction with leading universities such as USC.
Grant funding is rare for HG. Please support our research.
Popular Publications
- Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes -- ScienceDirect Opinion, 2024
- GDF15 linked to maternal risk of nausea and vomiting during pregnancy -- Nature Journal, 2023
- Pregnant, Miserable, and Starving in 21st Century America
--AJOG Clinical Opinion, 2022 - HyperEmesis Level Prediction (HELP Score) Identifies Patients with Indicators of Severe Disease: a Validation Study -- Geburtsh Frauenheilk, 2021 (German & English)
- A patient–clinician James Lind Alliance partnership to identify research priorities for hyperemesis gravidarum ( opens in new tab) -- BMJ, 2020
- Nausea and vomiting of pregnancy and hyperemesis gravidarum
-- NATURE REVIEWS | Disease Primers, 2019 (Supplemental material; poster)
Research Studies by Subject
Other Resources
Other Research & Presentations
- Performance of iPhone Hyperemesis Gravidarum Care App
-- J Clinical Case Rep Case Studies, 2019 - SMFM 2019 Genetics Poster
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HER Foundation FCOI Policy
- NIH FCOI Policy
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